Chapter 001

PART I: PRINCIPLES OF PHARMACOLOGY

Pharmacodynamics: Mechanisms of Drug Action

Frank J. Dowd and Peter W. Abel

GENERAL REFERENCES

  1. Ariëns EJ, Simonis AM, van Rossum JM: Drug-receptor interactions: interaction of one or more drugs with one receptor system. In Ariëns EJ, editor: Molecular pharmacology: mode of action of biologically active compounds, New York, 1964, Academic Press.
  2. Bhattacharya S, Hall SE, Li H, et al.: Ligand-stabilized conformational states of human ƈ2 adrenergic receptor: insight into G-protein-coupled receptor activation, Biophys J 94:2027–2042, 2008. PUBMED Abstract
  3. Clark AJ: The reaction between acetyl choline and muscle cells. Part II, J Physiol 64:123–143, 1927. PUBMED Abstract
  4. Heng BC, Aubel D, Fussenegger M: G Protein-coupled receptors revisited: therapeutic applications inspired by synthetic biology, Annu Rev Pharmacol Tox 54:227–249, 2014. PUBMED Abstract
  5. IUPHAR/BPS Guide to Pharmacology (contains receptor classifications and nomenclature) (on the web) http://www.guidetopharmacology.org/ (accessed 2015). PUBMED Abstract
  6. Katritch V, Cherezov V, Stevens RC: Diversity and modularity of G protein-coupled receptor structures, Trends Pharmacol Sci 33:17–27, 2012. PUBMED Abstract
  7. Kenakin T: Principles: receptor theory in pharmacology, Trends Pharmacol Sci 25:186–192, 2004. PUBMED Abstract
  8. Kobilka BK: Structural insights into adrenergic receptor function and pharmacology, Trends Pharmacol Sci 32:213–218, 2011. PUBMED Abstract
  9. Rosenbaum DM, Rasmussen SG, Kobilka BK: The structure and function of G protein-coupled receptors, Nature 459:356–363, 2009. PUBMED Abstract
  10. Urban JD, Clarke WP, von Zastrow M, et al.: Functional selectivity and classical concepts of quantitative pharmacology, J Pharmacol Exp Ther 320:1–13, 2007. PUBMED Abstract
  11. Wenthur CJ, Gentry PR, Mathews TP, Lindsley CW: Drugs for allosteric sites on receptors, Annu Rev Pharmacol Tox 54:165–184, 2014. PUBMED Abstract