Chapter 001

PART I: PRINCIPLES OF PHARMACOLOGY

Pharmacodynamics: Mechanisms of Drug Action

John A. Yagiela

CITED REFERENCES

  1. Ariëns EJ, Simonis AM, van Rossum JM: Drug-receptor interactions: interaction of one or more drugs with one receptor system. In Ariëns EJ, editor: Molecular pharmacology: mode of action of biologically active compounds, New York, 1964, Academic Press.
  2. Bhattacharya S, Hall SE, Li H, et al: Ligand-stabilized conformational states of human β2 adrenergic receptor: insight into G-protein-coupled receptor activation, Biophys J 94:2027-2042, 2008. PUBMED Abstract
  3. Bourne HR, von Zastrow M: Drug receptors and pharmacodynamics. In Katzung BG, editor: Basic and clinical pharmacology, ed 10, New York, 2007, McGraw-Hill Professional.
  4. Deuel TF: Polypeptide growth factors: roles in normal and abnormal cell growth, Annu Rev Cell Biol 3:443-492, 1987. PUBMED Abstract
  5. Dougherty DA: Cation-π interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp, Science 271:163-168, 1996. PUBMED Abstract
  6. Ellis J, Warburton P, Donnelly D, et al: Conformational induction is the key process for activation of the AT1 receptor, Biochem Pharmacol 71:464-471, 2006.
  7. Franks NP: General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal, Nat Rev Neurosci 9:370-386, 2008. PUBMED Abstract
  8. Germain P, Staels B, Dacquet C, et al: Overview of nomenclature of nuclear receptors, Pharmacol Rev 58:685-704, 2006. PUBMED Abstract
  9. Gilman AG: G proteins: transducers of receptor-generated signals, Annu Rev Biochem 56:615-649, 1987. PUBMED Abstract
  10. Haefely WE: The benzodiazepine receptor and its clinically useful ligands, Clin Neuropharmacol 9(suppl 4):398-400, 1986.
  11. Hanson MA, Stevens RC: Discovery of new GPCR biology: one receptor structure at a time, Structure 17:8-14, 2009. PUBMED Abstract
  12. Karlin A, Cox RN, Dipaola M, et al: Functional domains of the nicotinic acetylcholine receptor, Ann N Y Acad Sci 463:53-69, 1986. PUBMED Abstract
  13. Kenakin T: Allosteric modulators: the new general of receptor antagonist, Mol Interv 4:222-229, 2004. PUBMED Abstract
  14. Kenakin T: Efficacy: molecular mechanisms and operational methods of measurement. In Kenakin T, Angus JA, editors: The pharmacology of functional, biochemical, and recombinant receptor systems. Handbook of experimental pharmacology, vol 148, Berlin, 2000, Springer-Verlag.
  15. Kenakin TP: The relative contribution of affinity and efficacy to agonist activity: organ selectivity of noradrenaline and oxymetazoline with reference to the classification of drug receptors, Br J Pharmacol 81:131-143, 1984.
  16. Mackay D: A critical survey of receptor theories of drug action. In van Rossum JM, editor: Kinetics of drug action. Handbook of experimental pharmacology, vol 47, Berlin, 1977, Springer-Verlag.
  17. Maren TH: The relation between enzyme inhibition and physiological response in the carbonic anhydrase system, J Pharmacol Exp Ther 139:140-153, 1963. PUBMED Abstract
  18. McDonnell DP, Wijayaratne A, Chang CY, et al: Elucidation of the molecular mechanism of action of selective estrogen receptor modulators, Am J Cardiol 90:35F-43F, 2002.
  19. Ruffolo RR Jr, Nichols AJ, Stadel JM, et al: Structure and function of α-adrenoceptors, Pharmacol Rev 43:475-505, 1991. PUBMED Abstract
  20. Surks MI, Oppenheimer JH: Concentration of l-thyroxine and l-triiodothyronine specifically bound to nuclear receptors in rat liver and kidney: quantitative evidence favoring a major role of T3 in thyroid hormone action, J Clin Invest 60:555-562, 1977.
  21. Taylor DR, Kennedy MA: Genetic variation of the β2-adrenoceptor: its functional and clinical importance in bronchial asthma, Am J Pharmacogenomics 1:165-174, 2001.
  22. Unwin N: Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution, J Mol Biol 346:967-989, 2005.
  23. Urban JD, Clarke WP, von Zasrow M, et al: Functional selectivity and classical concepts of quantitative pharmacology, J Pharmacol Exp Ther 320:1-13, 2007. PUBMED Abstract
  24. Virkamäki A, Ueki K, Kahn CR: Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance, J Clin Invest 103:931-943, 1999. PUBMED Abstract

GENERAL REFERENCES

  1. Bourne HR, von Zastrow M: Drug receptors and pharmacodynamics. In Katzung BG: Basic and clinical pharmacology, ed 10, New York, 2007, McGraw-Hill Professional.
  2. Buxton ILO: Pharmacokinetics and pharmacodynamics: the dynamics of drug absorption, distribution, action, and elimination. In Brunton LL, Lazo JS, Parker KL, editors: Goodman and Gilman’s the pharmacological basis of therapeutics, ed 11, New York, 2006, McGraw-Hill.
  3. Derendorf H, Hochhaus G, editors: Handbook of pharmacokinetic/pharmacodynamic correlation, Boca Raton, FL, 1995, CRC Press.
  4. Kenakin T, Angus JA, editors: The pharmacology of functional, biochemical, and recombinant receptor systems. Handbook of experimental pharmacology, vol 148, Berlin, 2000, Springer-Verlag.
  5. Pratt WB, Taylor P, editors: Principles of drug action: the basis of pharmacology, ed 3, New York, 1990, Churchill Livingstone.